Basic Information

Product Name： N,O-Bis(trimethylsilyl)trifluoroacetamide 

Type：DYJ-333

CAS No.: 25561-30-2

Technical Specifications

Appearance: Colorless clear liquid

Purity (GC): ≥99.0%

Density (20℃, g/mL): 0.960–0.970

Refractive Index (20℃): 1.383–1.385

Boiling Point: 40–50℃ (12–14 mmHg); ~142℃

(atmospheric)

Flash Point: 23–34℃

Melting Point: −41℃

Moisture: ≤0.1%

Solubility: Soluble in ether, acetone, chloroform;

hydrolyzes in water

Applications

1.Organic Synthesis (Silylation Protection): Powerful neutral silylating agent, fast reaction, mild conditions.
2.Analytical Chemistry (GC/GC-MS Derivatization): Ideal for non-volatile/thermolabile compounds, more volatile than BSA.
3.Pharmaceutical Intermediates: Key reagent in cephalosporins, nucleosides, peptides, and heterocyclic synthesis.
4.Electronics & Materials: Silicone resin/rubber modification, surface hydrophobization, adhesion promotion.
5.Catalysis & Organic Reactions: Used in fluorination, cross-coupling, N-silylation.