Basic Information

Product Name: N,O-Bis(trimethylsilyl)acetamide (BSA) 

Type: DYJ-303

CAS No.: 10416-59-8

Technical Specifications

Appearance: Colorless to pale yellow clear liquid

Purity (GC): ≥95% (typically ≥98%)

Density (20℃, g/mL): 0.829–0.832

Refractive Index (20℃): 1.4165–1.4185

Boiling Point: 71–73℃ (35 mmHg)

Flash Point: 42℃

Melting Point: −24℃

Moisture: ≤0.2%

Silyl Activity: ≥98%

Applications

1.Organic Synthesis (Silylation Protection)：Powerful silylating agent for protecting active hydrogens in hydroxyl, amino, carboxyl, amide, phenol, enol groups; enhances volatility and thermal stability for multi-step synthesis and purification。

2. Pharmaceutical Intermediate：Key reagent in cephalosporin antibiotics, nucleosides, peptides, heterocycles synthesis; enables mild silylation with high yield and purity。

3. Analytical Chemistry (GC/GC-MS Derivatization)：Derivatizing agent for non-volatile/thermolabile compounds (e.g., phenolic acids, sugars, amino acids, fatty acids); improves chromatographic performance and detection sensitivity。

4. Electronics & Materials：Used in silicone resin/rubber modification, chromatographic support deactivation, surface treatment and adhesion promotion。

5. Others：Brønsted base precursor in Tsuji–Trost reactions; reagent for regioselective desulfation of polysaccharide sulfates。